The cyanobacterial neurotoxin β-methylamino-L-alanine (L-BMAA) has been implicated in the etiology of neurodegenerative disease and proposed to be biomagnified in terrestrial and aquatic food chains. BMAA is known to misincorporate into nascent proteins in place of L-serine, causing protein misfolding and aggregation, both hallmarks of tangle diseases, including Alzheimer´s, Parkinson´s, ALS, PSP and Lewy Body Disease.
Novandi Chemistry can now offer carbon-14 labelled [1-14C]BMAA off the shelf. As it is labelled in a metabolically stable position [1-14C]BMAA is suitable for studying i.e. the metabolism and environmental fate of this neurotoxin. Available is also the carbon-14 labelled corresponding D-form of BMAA.
[1-14C]BMAA is delivered with short notice by courier service and is accompanied with a certificate of analysis.