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SMW139, [³H]

Tommy Anzelius7/5/2021|
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Purinergic P2X7 receptor allosteric antagonist

  • Catalog number: NT1123
  • Molar activity: 75-87 Ci/mmol; 2.7-3.2 TBq/mmol
  • CAS Number (Parent): 2133010-38-3
  • Storage conditions: -20°C, in ethanol
  • Stability: The rate of decomposition is initially about 2% for 3 months
  • Notes: Shipped on dry ice. To inquire about the current price of this product, please mail us your inquiry below.
Catalog item no NT1123

References

  • “The P2X7 receptor tracer [11C]SMW139 as an in vivo marker of neuroinflammation in multiple sclerosis: a first-in man study” M. H. J. Hagens, S. S. V. Golla, B. Janssen, D. J. Vugts, W. Beaino, A. D. Windhorst, J. O’Brien-Brown, M. Kassiou, R. C. Schuit, L. A. Schwarte, H. E. de Vries, J. Killestein, F. Barkhof, B. N. M. van Berckel and A. A. Lammertsma (2020) Journal of Nuclear Medicine and Molecular Imaging 47 (2): 379-389.
  • “Identification of the allosteric P2X7 receptor antagonist [11C]SMW139 as a PET tracer of microglial activation” B. Janssen, D. J. Vugts, S. M. Wilkinson, D. Ory, S. Chalon, J. J. M. Hoozemans, R. C. Schuit , W. Beaino, E. J. M. Kooijman, J. van den Hoek, M. Chishty, A. Doméné, A. Van der Perren, A. Villa, A. Maggi, G. T. Molenaar, U. Funke, R. V. Shevchenko, V. Baekelandt, G. Bormans, A. A. Lammertsma, M. Kassiou and A. D. Windhorst (2018)  Scientific Reports 8 (1): 6580.
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