Muscarinic M4 receptor positive allosteric modulator (PAM)
- Catalog number: NT1133
- Alternate name: MK6884
- Molar activity: 75-87 Ci/mmol; 2.7-3.2 TBq/mmol
- Concentration: 1.0 mCi/mL
- CAS Number (Parent): 2102194-04-5
- Storage conditions: -20°C, in ethanol
- Stability: The rate of decomposition is initially about 4% for 6 months
- Notes: Shipped on dry ice. To inquire about the current price of this product, please mail us your inquiry below.
References
- “Discovery of [11C]MK-6884: A Positron Emission Tomography (PET) Imaging Agent for the Study of M4 Muscarinic Receptor Positive Allosteric Modulators (PAMs) in Neurodegenerative Diseases” L. Tong , W. Li, M. M.-C. Lo, X. Gao, J. M.-C. Wai, M. Rudd, D. Tellers, A. Joshi, Z. Zeng, P. Miller, C. Salinas, K. Riffel, H. Haley, M. Purcell, M. Holahan, L. Gantert, J. W. Schubert, K. Jones, J. Mulhearn, M. Egbertson, Z. Meng, B. Hanney, R. Gomez, S. T. Harrison, P. McQuade, T. Bueters, J. Uslaner, J. Morrow, F. Thomson, J. Kong, J. Liao, O. Selyutin, J. Bao, N. B. Hastings, S. Agrawal, B. C. Magliaro, F. J. Monsma Jr, M. D. Smith, S. Risso, D. Hesk, E. Hostetler and R. Mazzola (2020) Journal of Medicinal Chemistry 63(5):2411-2425.
- “The PET tracer 11C]MK-6884 quantifies M4 muscarinic receptor in rhesus monkeys and patients with Alzheimer’s disease” W. Li, Y. Wang, T. G. Lohith, Z. Zeng, L. Tong, R. Mazzola, K. Riffel, P. Miller, M. Purcell, M. Holahan, H. Haley, L. Gantert, D. Hesk, S. Ren, J. Morrow, J. Uslaner, A. Struyk, J. M.-C. Wai, M. T. Rudd, D. M. Tellers, T. McAvoy, G. Bormans, M. Koole, K. Van Laere, K. Serdons, J. de Hoon, R. Declercq, I. De Lepeleire, M. B. Pascual, P. Zanotti-Fregonara, M. Yu, V. Arbones, J. C. Masdeu, A. Cheng, A. Hussain, T. Bueters, M. S. Anderson, E. D. Hostetler and A. S. Basile (2022) Science Translational Medicine 14(627).
